Ghafouri, Hamed Basir and Zare, Morteza and Bazrafshan, Azam and Edalatkhah, Abbas and Abazarian, Niloofar (2016) Azithromycin versus Cephalexin for Simple Traumatic Wounds in the Emergency Department: A Randomised Trial. Global Journal of Health Science, 8 (10). p. 185. ISSN 1916-9736
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Abstract
OBJECTIVE: The aim of this study was to investigate efficacy of azithromycin versus cephalexin for infection prophylaxisis in patients with simple traumatic wounds managed at emergency department.
METHOD: This randomized controlled trial compared short-course therapy of once-daily azithromycin (500 mg before the wound repair followed by 250 mg/day for 5 days) with cephalexin (1000 mg before wound repair followed by 250 mg every 6 hours for 5 days) in the treatment of patients with simple traumatic wounds. A total of 366 patients were randomly selected for the study and 303 were evaluated for the final analysis.
RESULTS: On completion of therapy, the rate of observed infection was 9.6% in the cephalexin group (15 patients, odds ratio=0.77, 95% confidence interval, 0.56 to 1.06) and 5.4% in the azithromycin group (8 patients, odds ratio 1.42, 95% confidence interval, 0.80 to 2.52). Both treatment indicated similar prophylactic efficacy during the study (P=0.197).
CONCLUSION: Our study showed that Azithromycin as infection prophylaxis in simple traumatic wounds had the same effect as cephalexin but azithromycin is easier to use and more cost-effective compared to cephalexin.
Item Type: | Article |
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Subjects: | Bengali Archive > Medical Science |
Depositing User: | Unnamed user with email support@bengaliarchive.com |
Date Deposited: | 04 May 2023 07:25 |
Last Modified: | 23 Sep 2024 04:42 |
URI: | http://science.archiveopenbook.com/id/eprint/1013 |