Adeboye, S and Ogundajo, A and Ajayi, O and Oluba, O (2017) Archachatina marginata Haemolymph Potentiates Hypoglycemic Effect by Mimicking Insulin in Streptozotocin-Induced Diabetic Rat. Journal of Pharmaceutical Research International, 18 (1). pp. 1-8. ISSN 24569119
Ogundajo1812017JPRI33786.pdf - Published Version
Download (155kB)
Abstract
Aims: This study investigates the hypoglycemic potential of Archachatina marginata haemolymph and its mechanism in streptozotocin -induced diabetic rats.
Study Design: One factor experimental design.
Place and Duration of Study: Department of Chemical Sciences, Joseph Ayo Babalola University, Ikeji Arakeji, Osun State, Nigeria between January to June, 2015.
Methodology: The rats were set into four groups (n=5). Group 1 - Non-diabetic control (NDC), Group 2 - Diabetic Control (DC), Group 3 - Diabetic rats with 1 mL administration of snail haemolymph (DSS1), Group 4 - Diabetic rats with 2 mL snail haemolymph administration (DSS2). The blood glucose concentration of each rat was taken and thereafter, they were weighed and then administered with 55 mg/kg STZ in citrate buffer (pH 4.5) peritoneally non-diabetic control group (NDC). Rats with blood glucose level of 200 mg/dL and above were considered diabetic. Haemolymph of 1 mL and 2 mL were administered to rats in DSS1 and DSS2 respectively while DC received 2 mL distilled water for 14 consecutive days. Physiological orangs and blood samples were harvested for various analysis.
Results: The A. marginata haemolymph significantly improved the plasma concentration of insulin and reduced plasma glucose level in a dose dependent manner P=.05.
Conclusion: The A. marginata haemolymph has potential to exact hypoglycemic effect and improve the insulin concentration in streptozotocin induced diabetic rat.
Item Type: | Article |
---|---|
Subjects: | Bengali Archive > Medical Science |
Depositing User: | Unnamed user with email support@bengaliarchive.com |
Date Deposited: | 26 May 2023 06:55 |
Last Modified: | 20 Jul 2024 09:48 |
URI: | http://science.archiveopenbook.com/id/eprint/1156 |