Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis

Shen, Jiayi and Zhou, Huaqiang and Liu, Jiaqing and Zhang, Yaxiong and Zhou, Ting and Chen, Gang and Fang, Wenfeng and Yang, Yunpeng and Huang, Yan and Zhang, Li (2021) Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis. Frontiers in Genetics, 12. ISSN 1664-8021

[thumbnail of pubmed-zip/versions/1/package-entries/fgene-12-756908/fgene-12-756908.pdf] Text
pubmed-zip/versions/1/package-entries/fgene-12-756908/fgene-12-756908.pdf - Published Version

Download (615kB)

Abstract

Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer death worldwide, making its prevention an urgent issue. Meanwhile, the estimated prevalence of insomnia was as high as 30% globally. Research on the causal effect of insomnia on lung cancer incidence is still lacking. In this study, we aimed to assess the causality between the genetic liability to insomnia and lung cancer. We performed a two-sample Mendelian randomization analysis (inverse variance weighted) to determine the causality between the genetic liability to insomnia and lung cancer. Subgroup analysis was conducted, which included lung adenocarcinoma and lung squamous cell carcinoma. In the sensitivity analysis, we conducted heterogeneity test, MR Egger, single SNP analysis, leave-one-out analysis, and MR PRESSO. There were causalities between the genetic susceptibility to insomnia and increased incidence of lung cancer [odds ratio (95% confidence interval), 1.35 (1.14–1.59); P, < 0.001], lung adenocarcinoma [odds ratio (95% confidence interval), 1.35 (1.07–1.70); P, 0.01], and lung squamous cell carcinoma [odds ratio (95% confidence interval), 1.35 (1.06–1.72), P, 0.02]. No violation of Mendelian randomization assumptions was observed in the sensitivity analysis. There was a causal relationship between the genetic susceptibility to insomnia and the lung cancer, which was also observed in lung adenocarcinoma and lung squamous cell carcinoma. The underlying mechanism remains unknown. Effective intervention and management for insomnia were recommended to improve the sleep quality and to prevent lung cancer. Moreover, regular screening for lung cancer may be beneficial for patients with insomnia.

Item Type: Article
Subjects: Bengali Archive > Medical Science
Depositing User: Unnamed user with email support@bengaliarchive.com
Date Deposited: 25 Jan 2023 11:14
Last Modified: 07 Jun 2024 10:54
URI: http://science.archiveopenbook.com/id/eprint/21

Actions (login required)

View Item
View Item