Soliman, Mohamed Mohamed and Ahmed, Mohamed Mohamed and El-Shazly, Samir Ahmed and Ismail, Tamer Ahmed and Attia, Hossam Fouad and Elkirdasy, Ahmed Farag (2014) Effect of vitamin A and E on carbohydrate and lipid metabolism in diet-induced obese wistar rats. Advances in Bioscience and Biotechnology, 05 (01). pp. 4-11. ISSN 2156-8456
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Abstract
In the present study, we investigated the biochemical alterations and gene expression of carbohydrate and lipid metabolism after oral administration of vitamin A and E for 2 months in diet-induced obese Wistar rats. Vitamin A and E administration reduced significantly the increase in body weight and food intake and normalized the alterations in lipid profiles in obese rats compared to normal rats. Moreover, both vitamins decreased the fat accumulation in liver tissues of obese rats. Finally, they up-regulated mRNA expression of Pyruvate Kinase (PK) and Glucose Transporter-2 (GLUT-2), and increased lipolysis and cholesterol metabolism through up-regulation of lipoprotein lipase (LPL), Sterol Responsible Element Binding Protein-1a (STREBP-1a) and STREBP-1c mRNA expression. In conclusion, vitamin A and E regulate gene expression of carbohydrate and lipid metabolism, and also ameliorate changes associated with obesity induced by high fat diet in Wistar rats.
Item Type: | Article |
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Subjects: | Bengali Archive > Biological Science |
Depositing User: | Unnamed user with email support@bengaliarchive.com |
Date Deposited: | 11 Mar 2023 09:40 |
Last Modified: | 07 Sep 2024 10:45 |
URI: | http://science.archiveopenbook.com/id/eprint/428 |