Optical Clearing of the Gastric Mucosa Using 40%-glucose Solution

The kinetics of collimated transmittance of the gastric mucosa under the action of an aqueous 40%-glucose solution was experimentally investigated. Based on the analysis of the transmittance kinetics, the value of the effective diffusion coefficient of glucose in the gastric mucosa was estimated and amounted to (1.59±0.96)×10-6 cm2/s. The permeability coefficient of the mucosa for glucose, calculated using the first Fick diffusion law, was estimated as (2.81±0.90)×10-5 cm/s. It was shown that the introduction of the glucose solution into the mucosa reduced the light scattering coefficient by approximately 5–10%. The increase in the depth of light penetration was from 5% to 15%, depending on the selected spectral range. The results can be used to develop new methods of diagnosis and treatment of stomach diseases.